Preclinical evaluation

16
SIX-MONTH SYSTEMS TOXICOLOGY INHALATION/CESSATION STUDY IN APOE−/− MICE TO INVESTIGATE CARDIOVASCULAR AND RESPIRATORY EXPOSURE EFFECTS OF TWO REDUCED RISK PRODUCTS COMPARED WITH CONVENTIONAL CIGARETTES
Blaine Phillips, Justyna Szostak, J. Ho, Emmanuel Guedj, Ee.Tsin Wong, Marja Talikka, Stefan Lebrun, Bjoern Titz, Florian Martin, Gregory Vuillaume, Patrice Leroy, Nicolai Ivanov, Patrick Vanscheeuwijck, Manuel C. Peitsch, and Julia Hoeng*

17
ASSESSMENT OF THE gloTM TOBACCO HEATING PRODUCT: TRADITIONAL AND 21ST CENTURY TOXICOLOGY APPROACHES
Ioanna Vardakou*, Damien Breheny, Jason Adamson, Andrew Baxter, Ian Crooks, Tomasz Jaunky, Mark Taylor, David Thorne, Chuan Liu, James Murphy, Marianna Gaca

18
SYSTEMS TOXICOLOGY ASSESSMENT OF FLAVORS COMPOUNDS PRESENT IN E-VAPOR PRODUCTS USING HUMAN PRIMARY BRONCHIAL EPITHELIAL CELLS
Diego Marescotti*, Carole Mathis, Stefano Acali, Vincenzo Belcastro, Ignacio Gonzalez Suarez, Stefan Frentzel, Davide Sciuscio, Estela Fernandes, Matteo Biasioli, Matthieu Fuhrimann, Felix Frauendorfer, Marco Esposito, Julia Hoeng, and Manuel C. Peitsch

19
IN VIVO QUANTIFICATION AND PHARMACOKINETIC STUDIES OF COTININE IN MICE BY LC-MS/MS
Mohamed A. El Mubarak, Charikleia Danika*, Charlyne Cachon, Charalambia Korovila, Korina Atsopardi, Nikolaos Panagopoulos, Konstantinos Farsalinos, Marigoula Margarity, Konstantinos Poulas, Gregory B. Sivolapenko

20
REDUCED RISK NICOTINE PRODUCTS vs CIGARETTE SMOKE: COMPARISON OF THEIR EFFECTS IN THE RESPIRATORY TRACT AND THE ADIPOSE TISSUE OF MICE
Zoi Zagoriti*, Mohamed A. El Mubarak, Konstantinos Farsalinos, Stavros Topouzis

21
NETWORK ANALYSIS FOR THE PRECLINICAL EVALUATION OF CHEMICALS: APPLICATION IN PRIMARY BRONCHIAL EPITHELIAL CELLS AS IN-VITRO MODELS FOR THE EFFECT OF TOBACCO PRODUCTS
Nikos Tsolakos, Asier Antoranz, Chris Fotis, Vicky Pliaka, Michalis Fragkos, Angeliki Minia, Leonidas G. Alexopoulos*

22
DETECTION AND QUANTIFICATION OF NICOTINE AND ITS METABOLITES IN SALIVA OF SMOKERS USING RAMAN SPECTROSCOPY
Aggeliki Kapnisi*, Christos Kontoyannis, Konstantinos Poulas, and Malvina Orkoula

*Presenting Author

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